Isoflurane metabolism

The rank order of anesthetic metabolism, assessed by fluoride production at saturating substrate concentrations, was methoxyflurane > sevoflurane > enflurane > isoflurane > desflurane > 0. There was a significant linear correlation of sevoflurane and methoxyflurane defluorination with antigenic P450 2E1 content (r = 0.98 and r = 0.72 ...

In addition, interaction with ketamine, used as a preanesthetic in this study, might differ between propofol and isoflurane. Metabolism was studied more than 4 hours after ketamine, and therefore we believe it is an unlikely contributor to the differences we noted between the two groups.
1. The influence of strain and sex on the effect of enflurane and isoflurane and administration on heme metabolism was investigated to identify the animal model which could best reproduce the biochemical signs of acute intermittent porphyria. 2.
The rank order of anesthetic metabolism, assessed by fluoride production at saturating substrate concentrations, was methoxyflurane > sevoflurane > enflurane > isoflurane > desflurane > 0. There was a significant linear correlation of sevoflurane and methoxyflurane defluorination with antigenic P450 2E1 content (r = 0.98 and r = 0.72 ...
The purpose of this study was to determine the effects of isoflurane, sevoflurane, propofol and alfaxalone on the canine brain metabolite bioprofile, measured with single voxel short echo time proton magnetic resonance spectroscopy at 3 Tesla. Ten adult healthy Beagle dogs were assigned to receive isoflurane, sevoflurane, propofol and alfaxalone at 3 different dose rates each in a randomized ...
Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. ... etc.) An increase in overall metabolism may be reflected in an elevated temperature, (which may rise rapidly early or late in the case, but usually is not the first sign of augmented ...
Both volatile and intravenous general anesthetics allosterically enhance γ-aminobutyric acid (GABA)-evoked chloride currents at the GABA type A (GABAA) receptor. Recent work has revealed that two specific amino acid residues within transmembrane domain (TM)2 and TM3 are necessary for positive modulation of GABAA and glycine receptors by the volatile anesthetic enflurane.
Isoflurane is well known to inhibit insulin secretion in rats, humans, and dogs, concomitantly causing an increase in glucose concentrations or glucose intolerance by changing normal protein, fatty acid, and glucose metabolism. 5,30,49 The current study also found that rats anesthetized with isoflurane had an abolished TFA rhythm, hyperglycemia ...
Isoflurane anesthesia alters the blood levels of several neuroendocrine hormones associated with normal metabolism and physiology and increases stress, but the effect of brief CO 2 anesthesia on these parameters is unknown. In this study, we examined the effects of isoflurane (4%) compared with brief CO 2 (70% CO 2, 30% air) anesthesia on circadian rhythms of plasma measures of physiology and ...
Definition. All inhalational agents, including isoflurane, decrease cerebral metabolic rate of oxygen (CMRO2). It is known that isoflurane can cause burst-suppression as well. The CMRO2-decreasing effect does not seem to be significantly different between isoflurane, sevoflurane, and desflurane. All intravenous induction agents, except ketamine ...
Definition. All inhalational agents, including isoflurane, decrease cerebral metabolic rate of oxygen (CMRO2). It is known that isoflurane can cause burst-suppression as well. The CMRO2-decreasing effect does not seem to be significantly different between isoflurane, sevoflurane, and desflurane. All intravenous induction agents, except ketamine ...
FORANE (isoflurane, USP) liquid for inhalation DESCRIPTION FORANE (isoflurane, USP), a nonflammable liquid administered by vaporizing, is a general inhalation anesthetic drug. It is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, and its structural formula is: Some physical constants are: Molecular weight 184.5
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